Nicole Duennebier was born in Hartford, Connecticut in 1983. She received her Bachelor of Fine Arts at Maine College of Art with a major in painting. Her BFA thesis work was most influenced by research into the coastal ecosystems of Maine. In 2006 she was awarded the Monhegan Island Artists Residency. On the island she continued her work with sea life, and perceived a natural connection between the darkness and intricacy of undersea regions and the aesthetic of 16th-century Dutch still-life painting. She is a 2016 Massachusetts Cultural Council Painting Fellow and her work can be found in the permanent collection of the New Britain Museum of American Art.
Duennebier has also been featured in the Portland Press Herald, Art New England and Hi-Fructose Magazine, among other publications. Earlier this year, she was featured in a solo exhibition, Pushing Painting, at the David Winton Bell Gallery at Brown University.